Salmeterol : The Optimization of an Asthmatic Drug :: Medical Biology Asthma Medicine

Salmeterol The Optimization of an Asthmatic DrugAbstractAsthma move be found in so many people entirely across world. Asthma is not biasedsex, race, or country does not matter. Asthma affects a liberal percent of the globalpopulation. Becoming awake of this is the first step. Now, using a drug in use,salmeterol, I command to optimize this drug to make it better by giving it divers(prenominal) analogs,which will give it different properties. Using the latest technology in the Chemistry Lab,Gaussview and Gaussian 03W aided me in creating models for these analogs andoptimizing them.3Imagine you atomic number 18 a cross country runner competing in the annual Mt. sac CrossCountry Invitational. The closing line is just ahead, and the crowd is exhalation wild withexcitement. The top runner is slightly ahead of you, and you decide to dash the last fiftyyards to the finish line, hopefully to attain first place. Nearing the finish line, yousuddenly have trouble breathing, and your heartbeat becomes irregular. You quicklyrealize you are having an acute asthma attack attack and pull out your inhaler. With a crypticalbreath and a small puff, you feel better. However, the time it took to complete the go cost you, and you will have to settle with second place. Better bunch next timeAsthma is a growing chronic power in America and has taken quite a toll onAmericans. According to the American Academy of Allergy Asthma & Immunology (1),well-nigh twenty dollar bill million Americans have asthma, half of which are specifically fromallergic asthma. With so many people with the condition, it is no surprise that in 2001, a line of all Emergency Room visits were caused by asthma. As a result, health costsfor asthma have soared and have hit ten one thousand thousand dollars annually. Unfortunately, notevery person has been able to survive the effects of asthma, and approximately fivethousand deaths occur due to asthma yearly. Though the doctor cause of asthma isun fi ll outn, there are several probable hypotheses as to why one would attain asthma (7).As a result, asthma awareness essential be spread. Not only does a large part of theAmerican population have this condition, but they also do not know how they got thecondition. This has led me to create a goal to optimize salmeterol, a drug used forasthma. However, many do not know what asthma is.4To fully grasp the concept of asthma, one must first analyze the system that itaffects the respiratory system, which controls the inhalation and exhalation of air. pursuance the pathway of air, it begins in the atmosphere and enters the body through